International Journal of Pharmaceutical and Life Sciences https://ijlsbd.com/index.php/01 <p>International Journal of Pharmaceutical and Life Sciences (IJPLS) is international, open access, peer-reviewed e-journal. IJPLS will be published monthly. IJPLS will publish original research papers, review articles, and conceptual articles on pharmaceutical and life sciences.</p> <p>IJPLS will publish original research papers, review articles, and conceptual articles on the following area of Pharmaceutical Sciences-</p> <p>Pharmacognosy, Pharmacology, Pharmaceutical Technology, Pharmaceutics, Pharmaceutical Analysis, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Quality Assurance of Pharmaceuticals, Regulatory/Industrial Affairs of Pharmaceuticals</p> <p>IJPLS will publish original research papers, review articles, and conceptual articles on the following area of Life Sciences-</p> <p>Chemistry, Botany, Zoology, Microbiology, Biochemistry, Biotechnology, Public Health</p> <p> </p> <p><strong>The next issue will be published in the first week of February 2022.</strong></p> One Quality Solutions en-US International Journal of Pharmaceutical and Life Sciences 2305-0330 GALACTOSYLATED ALBUMIN NANOPARTICLES BEARING CIMETIDINE https://ijlsbd.com/index.php/01/article/view/43 <p>The galacotsylated albumin nanoparticles were prepared for the selective delivery of Cimetidine to the asialoglycoprotein receptor (ASGP-R) which is particularly presents on mammalian hepatocytes. The albumin nanoparticles (NPs) were prepared by using desolvation method and efficiently conjugated with galactose. Various parameters such as particle size, % entrapment efficiency and drug loading efficiency, percentage yield, in vitro drug release, were determined. The size of nanoparticles (both plain and galactose coated) was found to be in range of 200-250 nm, and maximum drug payload was found to be 19.08% ± 1.10 .The maximum drug content was found to be 30.80% ± 0.3 and 27.09% ± 0.5 respectively in plain and galactose coated nanoparticles while the maximum entrapment efficiency was found to be 90.68% ± 0.5 and 91.75% ± 0.59 in plain and coated nanoparticles. It was also found that coating of nanoparticles increases the size of nanoparticles. From the in-vitro studies, it was concluded that increase in polymer concentration, decreases the drug releases from the nanoparticles.</p> Dhyani Archana Kumar Ganesh Kothiyal Preeti Copyright (c) 2022 International Journal of Pharmaceutical and Life Sciences 2013-12-01 2013-12-01 2 5 202 229 10.3329/ijpls.v2i5.43 A CHRONOPHARMACOLOGICAL STUDY RELATED TO DOXORUBICIN BASED BONE MARROW SUPPRESSION https://ijlsbd.com/index.php/01/article/view/42 <p>Myelosuppression is the most common toxicity of anti-neoplastic therapy due to inhibition of cell replication in bone marrow. This can be minimized by administering drugs on the basis of circadian time basis. Hence the aim is to study circadian time cycle related bone marrow suppression variation resulting from doxorubicin based cancer chemo therapy regimen. A prospective observational clinical study based on circadian time Cycle was done for a period of six months at a tertiary care hospital. Standard doxorubicin Regimen was given in the dose of 60 mg/m as iv infusion. Each cycle is repeated every 21 Days. Complete hemogram was done on day 0 and day 10 of both day and night cycle. Results were analyzed using students paired t test .It was found that during Night cycle therapy bone marrow suppression was minimal and statistically significant (p&lt;0.001). Chronotherapy is useful in minimizing bone marrow toxicity.</p> Dr. Vijayalakshmi Subbiah Dr. Rajendran K. Dr. Shanthi M. Dr. Parameswari R. Copyright (c) 2022 International Journal of Pharmaceutical and Life Sciences 2013-12-01 2013-12-01 2 5 197 201 10.3329/ijpls.v2i5.42